期刊
MOLECULAR PSYCHIATRY
卷 15, 期 5, 页码 548-558出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2008.102
关键词
parenting; dopamine transporter gene; genetics; disruptive behavior; child effects
资金
- National Institute of Mental Health [2RO1 MH053554, T32 MH200065-01]
- Jean Young and Walden W Shaw Foundation
Although maternal parenting is central to child development, little is known about the interplay between molecular genetic and environmental factors that influence parenting. We tested the association of the 40-bp variable number tandem repeat polymorphism of the dopamine transporter (DAT1; SLC6A3) gene with three dimensions of observed maternal parenting behavior (positive parenting, negative parenting and total maternal commands). A significant nonadditive association was found between maternal DAT1 genotype and both negative parenting and total commands during a structured mother-child interaction task, even after controlling demographic factors, maternal psychopathology and disruptive child behavior during the task. Furthermore, the association between maternal DAT1 genotype and negative parenting was significantly stronger among mothers whose children were highly disruptive during the mother-child interaction task, suggesting a gene-environment interaction. Molecular Psychiatry (2010) 15, 548-558; doi:10.1038/mp.2008.102; published online 9 September 2008
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据