期刊
MOLECULAR PLANT
卷 7, 期 7, 页码 1138-1150出版社
CELL PRESS
DOI: 10.1093/mp/ssu071
关键词
mitochondrial perturbation; auxin signaling; retrograde communication
资金
- Ghent University (Multidisciplinary Research Partnership 'Biotechnology for a Sustainable Economy') [01MRB510W]
- Agency for Innovation by Science and Technology (IWT
- Phoenix project) [070347]
- VIB
- Marie Curie (OMICS@VIB) [PCOFUND-GA-2010-267139]
- Interuniversity Attraction Poles Programme [IUAP P7/29 'MARS']
- Belgian Science Policy Office
- Marie Currie fellowship
- FWO (Fonds Wetenschappelijk Onderzoek-Vlaanderen)
- IWT
Mitochondria are crucial players in the signaling and metabolic homeostasis of the plant cell. The molecular components that orchestrate the underlying processes, however, are largely unknown. Using a chemical biology approach, we exploited the responsiveness of Arabidopsis UDP-glucosyltransferase-encoding UGT74E2 towards mitochondrial perturbation in order to look for novel mechanisms regulating mitochondria-to-nucleus communication. The most potent inducers of UGT74E2 shared a (2-furyl) acrylate (FAA) substructure that negatively affected mitochondrial function and was identified before as an auxin transcriptional inhibitor. Based on these premises, we demonstrated that perturbed mitochondria negatively affect the auxin signaling machinery. Moreover, chemical perturbation of polar auxin transport and auxin biosynthesis was sufficient to induce mitochondrial retrograde markers and their transcript abundance was constitutively elevated in the absence of the auxin transcriptional activators ARF7 and ARF19.
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