期刊
MOLECULAR PHARMACEUTICS
卷 12, 期 2, 页码 474-483出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp500563n
关键词
hydrogels; swelling; controlled release; transport phenomena; modeling
资金
- Ministero dell'Istruzione dell'Universita e della Ricerca [PRIN 2010-11-20109PLMH2]
In this work the behavior of hydrogel-based matrices, the most widespread systems for oral controlled release of pharmaceuticals, has been mathematically described. In addition, the calculations of the model have been validated against a rich set of experimental data obtained working with tablets made of hydroxypropyl methylcellulose (a hydrogel) and theophylline (a model drug). The model takes into account water uptake, hydrogel swelling, drug release, and polymer erosion. The model was obtained as an improvement of a previous code, describing the diffusion in concentrated systems, and obtaining the erosion front (which is a moving boundary) from the polymer mass balance (in this way, the number of fitting parameters was also reduced by one). The proposed model was found able to describe all the observed phenomena, and then it can be considered a tool with predictive capabilities, useful in design and testing of new dosage systems based on hydrogels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据