期刊
MOLECULAR PHARMACEUTICS
卷 11, 期 1, 页码 226-233出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp4004018
关键词
camptothecin; pharmacokinetics; metastasis; nanocrystals; drug delivery
资金
- National Natural Science Foundation of China [81202470, 81130059]
- National Research Fund for Fundamental Key Project [2009CB930300]
- DOD BCRP [BC050287]
Cancer metastasis is difficult to treat, and its outcome becomes dreadful for a patient. Lung is a major metastatic site for many types of cancers, and the need for finding effective treatment for lung metastasis cannot be overemphasized. In a previous study, we showed that camptothecin nanocrystals demonstrated greater anticancer, efficacy and achieved significantly higher concentration in lungs than a conventional, solution-based formulation., In this study, we further determined the pharmacokinetics of camptothecin nanocrystals in rats and investigated treatment efficacy in mice against metastatic lung tumors. The results show that camptothecin nanocrystals were capable of eliciting greater antimetastatic efficacy and achieve a longer survival time in the murine model compared with camptothecin salt solution. The study suggests that using engineered, solid nanoparticles may be a feasible approach in the treatment of lung cancer and lung metastatic cancer.
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