期刊
MOLECULAR PHARMACEUTICS
卷 10, 期 7, 页码 2707-2712出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp4001298
关键词
drug delivery; shear stress; liposomes; cell viability; translocation
资金
- Lundbeckfonden, Denmark
- Danish council for independent research
An important aspect to ensure progress in biomedicine is the fundamental understanding of the interaction of cells and tissue with (bio)materials. The consideration of shear stress in drug delivery and/or tissue engineering remains largely unexplored. To illustrate the fundamental relevance, we employ a microfluidic setup to evaluate the myoblast cell response to two prominent rug carrier systems, namely, liposomes and nanoparticles, in the presence of low shear stress. We show that positively charged carriers have an enhanced interaction with myoblast cells in the presence of shear stress. This effect can e translated into improved therapeutic response in terms of reduction in cell viability when delivering a cytotoxic compound or into a better translocation efficiency when using lipoplexes. Taken together, our fundamental findings open up now Possibilities in tissue engineering and drug delivery by considering an additional parameter when delivering beneficial compounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据