期刊
MOLECULAR PHARMACEUTICS
卷 9, 期 11, 页码 3209-3217出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp300302g
关键词
trehalose; dielectric spectroscopy; molecular mobility; crystallization kinetics; crystallization onset; prediction; preparation method
资金
- NSF through the Materials Research Science and Engineering Centers (MRSEC) program
- William and Mildred Peters Endowment Fund
Amorphous trehalose was prepared by different methods, viz., freeze-drying, spray-drying and dehydration of trehalose dihydrate. The different molecular relaxations were characterized by dynamic dielectric spectroscopy. The preparation method significantly affected the structural relaxation time and its temperature dependence in the glassy region. The order of activation energy for alpha-relaxation was spray-dried > freeze-dried > dehydrated. However, the secondary relaxation times remained essentially unaffected by the preparation method. Isothermal crystallization kinetics was studied at several temperatures above the glass transition temperature (T-g). A linear correlation was observed between the crystallization time (inverse of crystallization rate constant) and the average alpha-relaxation time, suggesting a similar molecular origin for these two processes. There was also strong coupling of the crystallization onset time with global molecular mobility in the supercooled liquid region, enabling the development of predictive models. The observed experimental onset times were in excellent agreement with the predicted values at temperatures around and below T-g.
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