期刊
MOLECULAR PHARMACEUTICS
卷 9, 期 9, 页码 2770-2777出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp200613y
关键词
lipid bilayer; mesoporous silica; phosphorylated lipid; cytotoxicity; controlled release
资金
- U.S. National Science Foundation [CHE-0809521]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0809521] Funding Source: National Science Foundation
A controlled release system composed of mesoporous silica nanoparticles with covalently bound dipalmitoyl moieties supporting phosphorylated lipids has been successfully synthesized and characterized. This MSN system demonstrates controlled release of fluorescein molecules under disulfide reducing conditions. Flow cytometry analyses confirm increased biocompatibility of the resulting lipid bilayer MSNs (LB-MSNs) from nonfunctional MSNs. Fluorescently labeled LB-MSNs are examined via confocal fluorescent microscopy ex vivo and were found to enter both normal and cancer cell lines. The LB-MSNs presented here have potential to be used as rapid and diverse functionalized, stable liposome analogues for drug delivery.
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