期刊
MOLECULAR PHARMACEUTICS
卷 9, 期 3, 页码 448-457出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp200549c
关键词
viologen dendrimers; hemolysis; cytotoxicity; antibacterial activity; membrane fluidity
资金
- COST-European Cooperation in Science and Technology [TD0802]
- project Biological Properties and Biomedical Applications of Dendrimers
- Foundation for Polish Science [TEAM/2008-1/5]
- European Regional Development Fund
- CNRS (France)
- MAScIR (Moroccan Foundation for Advanced Science, Innovation and Research)
Some biological properties of eight dendrimers incorporating both phosphorus linkages and viologen units within their cascade structure or at the periphery were investigated for the first time. In particular cytotoxicity, hemotoxicity, and antimicrobial and antifungal activity of these new macromolecules were examined. Even if for example all these species exhibited good antimicrobial properties, it was demonstrated that their behavior strongly depends on several parameters as their size and molecular weight, the number of viologen units and the nature of the terminal groups.
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