期刊
MOLECULAR PHARMACEUTICS
卷 5, 期 2, 页码 191-211出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp700137g
关键词
nonribosomal peptide synthetase; natural products; peptide antibiotics; beta-lactams; glycopeptides
资金
- NIAID NIH HHS [AI065850, R01 AI065850, R01 AI065850-03] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI065850] Funding Source: NIH RePORTER
Natural products biosynthesized wholly or in part by nonribosomal peptide synthetases (NRPSs) are some of the most important drugs currently used clinically for the treatment of a variety of diseases. Since the initial research into NRPSs in the early 1960s, we have gained considerable insights into the mechanism by which these enzymes assemble these natural products. This review will present a brief history of how the basic mechanistic steps of NRPSs were initially deciphered and how this information has led us to understand how nature modified these systems to generate the enormous structural diversity seen in nonribosomal peptides. This review will also briefly discuss how drug development and discovery are being influenced by what we have learned from nature about nonribosomal peptide biosynthesis.
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