4.3 Review

Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy

期刊

MOLECULAR PAIN
卷 7, 期 -, 页码 -

出版社

SAGE PUBLICATIONS INC
DOI: 10.1186/1744-8069-7-20

关键词

-

资金

  1. Austrian Science Fund (FWF)
  2. National Natural Science Foundation of China [30570599]
  3. Pfizer
  4. Austrian Science Fund (FWF) [P 22306] Funding Source: researchfish

向作者/读者索取更多资源

Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in acute and chronic pain states. Spinal LTP is typically induced by noxious input and has therefore been hypothesized to contribute to acute postoperative pain and to forms of chronic pain that develop from an initial painful event, peripheral inflammation or neuropathy. Under this assumption, preventing LTP induction may help to prevent the development of exaggerated postoperative pain and reversing established LTP may help to treat patients who have an LTP component to their chronic pain. Spinal LTP is also induced by abrupt opioid withdrawal, making it a possible mechanism of some forms of opioid-induced hyperalgesia. Here, we give an overview of targets for preventing LTP induction and modifying established LTP as identified in animal studies. We discuss which of the various symptoms of human experimental and clinical pain may be manifestations of spinal LTP, review the pharmacology of these possible human LTP manifestations and compare it to the pharmacology of spinal LTP in rodents.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据