期刊
MOLECULAR ORAL MICROBIOLOGY
卷 25, 期 5, 页码 305-316出版社
WILEY
DOI: 10.1111/j.2041-1014.2010.00582.x
关键词
atherosclerosis; bacterial persistence; immune evasion; innate immunity; Porphyromonas gingivalis; Toll-like receptor
资金
- National Institutes of Health Public Health Service [HL080387]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL080387] Funding Source: NIH RePORTER
P>A hallmark of infection with the gram-negative pathogen Porphyromonas gingivalis is the induction of a chronic inflammatory response. P. gingivalis induces a local chronic inflammatory response that results in oral inflammatory bone destruction, which manifests as periodontal disease. In addition to chronic inflammation at the initial site of infection, mounting evidence has accumulated supporting a role for P. gingivalis-mediated periodontal disease as a risk factor for several systemic diseases including, diabetes, preterm birth, stroke, and atherosclerotic cardiovascular disease. A growing number of in vitro studies have demonstrated that P. gingivalis infection stimulates cell activation commensurate with expected responses paralleling inflammatory atherosclerotic-type responses. Furthermore, various mouse models have been used to examine the ability of P. gingivalis to stimulate chronic inflammatory plaque accumulation and recent studies have pointed to a pivotal role for innate immune signaling via the Toll-like receptors in the chronic inflammation associated with P. gingivalis infection. In this review we discuss the pathogen and host cell specificity of these responses and discuss possible mechanisms by which this oral pathogen can induce and maintain a chronic state of inflammation at sites distant from oral infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据