期刊
MOLECULAR ONCOLOGY
卷 7, 期 2, 页码 190-205出版社
WILEY
DOI: 10.1016/j.molonc.2013.02.005
关键词
Transgenic; Knock-out; Conditional somatic mutagenesis; Cre; Androgen; Stem cells
类别
资金
- Fondation ARC pour la recherche sur le cancer
- Ligue contre le Cancer
- Alsace contre le Cancer
- CNRS
- INSERM
- Universite de Strasbourg
Despite major improvement in treatment of early stage localised prostate cancer, the distinction between indolent tumors and those that will become aggressive, as well as the lack of efficient therapies of advanced prostate cancer, remain major health problems. Genetically engineered mice (GEM) have been extensively used to investigate the molecular and cellular mechanisms underlying prostate tumor initiation and progression, and to evaluate new therapies. Moreover, the recent development of conditional somatic mutagenesis in the mouse prostate offers the possibility to generate new models that more faithfully reproduce the human disease, and thus should contribute to improve diagnosis and treatments. The strengths and weaknesses of various models will be discussed, as well as future opportunities. (c) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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