期刊
MOLECULAR ONCOLOGY
卷 7, 期 3, 页码 452-463出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molonc.2012.11.004
关键词
Dnmt; Epigenetic; HDAC; NY-ESO1; Glioma; Mesothelioma
类别
资金
- Ligue contre le cancer Grand-Ouest (et plus particulierement par les comites departementaux de Loire-Atlantique, de Vendee, d'Ile et Vilaine, Morbihan et Sarthe)
- Association pour la Recherche et les Soils sur le mesotheliome [ARSMESO44]
The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies. Despite the identification of the epigenetical silencing of the NY-ESO1 gene in a large variety of tumors, the molecular mechanism involved in this phenomenon is not fully elucidated. In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes. Thus, our data illustrate the orchestration of a sequential epigenetic mechanism including the histone deacetylation and methylation, and the DNA methylation processes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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