期刊
MOLECULAR ONCOLOGY
卷 4, 期 5, 页码 385-396出版社
WILEY
DOI: 10.1016/j.molonc.2010.06.009
关键词
Prostate cancer; Cancer-initiation; Stem cell; Tissue-regeneration; Castration-resistance
类别
资金
- Institutional Ruth L. Kirschstein National Research Service Award
- Prostate Cancer Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007185] Funding Source: NIH RePORTER
Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue-regenerating stem cells in the adult organ? 2. Can tissue-regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor-propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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