期刊
MOLECULAR ONCOLOGY
卷 3, 期 4, 页码 354-365出版社
WILEY
DOI: 10.1016/j.molonc.2009.05.005
关键词
Endocytosis; Tumor suppression genes; Drosophila; Mitogenic signaling; Polarity; Apoptosis; Notch; EGFR; JNK; ESCRT
类别
资金
- American Heart Association [0825176F]
- Associazione Italiana Ricerca contro il Cancro
- National Institutes of Health [R01GM 068675]
- American Cancer Society [RSG-07-040-01]
Endocytosis is an important regulator of cell-cell signaling and endocytic trafficking has been increasingly implicated in control of tumor suppression. Recent insights from Drosophila indicate that impairment of multiple trafficking steps which lead to receptor degradation can cause tumor formation in epithelial organs. These tumors are characterized by sustained activation of a number of mitogenic signaling pathways, and by subversion of epithelial polarity and the apoptotic response. Cooperation between such alterations, as well as tumor-host interactions, is also observed. The recapitulation of several hallmarks of human cancers in fly tumors provides a framework to understand the role of defective endocytosis in cancer. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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