期刊
MOLECULAR ONCOLOGY
卷 2, 期 4, 页码 349-355出版社
WILEY
DOI: 10.1016/j.molonc.2008.09.001
关键词
CTC; Circulating tumour cells; Colorectal cancer; EGFR; EGFR variants
类别
资金
- AdnaGen AG
Circulating tumour cells (CTC) can be traced in patients with different types of cancer. The aim of this study was to detect CTC in patients with advanced colorectal cancer and whether CTC are still detectable after systemic chemotherapy. Blood from 34 patients with advanced colorectal cancer was analysed for the presence of CTC before chemotherapy was given and after 3 months. Eleven patients demonstrated a tumour remission after chemotherapy. In 6 cases CTC were detectable before but not after initiation of chemotherapy. Ten patients demonstrated a progression. In 5 cases CTC were detected before and after chemotherapy. Our data suggest that the detection of CTC will help to identify patients responding to chemotherapy or with a risk of a therapy failure. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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