期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 58, 期 11, 页码 2206-2218出版社
WILEY
DOI: 10.1002/mnfr.201400298
关键词
Arabinoxylan-oligosaccharides; Fecal water toxicity; Fermentation; Oligofructose
资金
- Fund for Scientific Research-Flanders (FWO Vlaanderen) Belgium (FWO project) [G.0674.10]
Scope: In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan-oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. Methods and results: Nineteen healthy subjects completed a double-blind, cross-over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2-wk wash-out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST-1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects ofWBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p-cresol (p=0.009) and isovaleric acid concentrations (p=0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake ofWBE (p=0.015). Both WBE- and oligofructose-intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. Conclusion: Structurally different prebiotics affect colonic fermentation and gut health in a different way.
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