期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 58, 期 3, 页码 601-613出版社
WILEY
DOI: 10.1002/mnfr.201300368
关键词
Endotoxemia; Fish oil; Inflammation; LPS; n-3 PUFA
资金
- UPenn Investigational Drug Services
- National Institutes of Health (NIH) [UL1RR024134, P20-DK 019525]
- NIH-NHLBI SCCOR Project grant [P50-HL-083799]
- American Heart Association [12POST11840017]
- Medical Research Council, UK [UD99999906]
- [RO1-HL-111694]
- [RO1-HL-113147]
- [RO1-DK-090505]
- [UO1-HL-108636]
- [K24-HL-107643]
- Medical Research Council [MC_UP_A090_1006] Funding Source: researchfish
- MRC [MC_UP_A090_1006] Funding Source: UKRI
ScopeFish oil-derived n-3 PUFA may improve cardiometabolic health through modulation of innate immunity. However, findings in clinical studies are conflicting. We hypothesized that n-3 PUFA supplementation would dose-dependently reduce the systemic inflammatory response to experimental endotoxemia in healthy humans. Methods and resultsThe Fenofibrate and omega-3 Fatty Acid Modulation of Endotoxemia (FFAME) study was an 8-wk randomized double-blind trial of placebo or n-3 PUFA supplementation (Lovaza 465 mg eicosapentaenoic acid (EPA) + 375 mg docosahexaenoic acid (DHA)) at low (1/day, 900 mg) or high (4/day, 3600 mg) dose in healthy individuals (N = 60; age 18-45; BMI 18-30; 43% female; 65% European-, 20% African-, 15% Asian-ancestry) before a low-dose endotoxin challenge (LPS 0.6 ng/kg intravenous bolus). The endotoxemia-induced temperature increase was significantly reduced with high-dose (p = 0.03) but not low-dose EPA + DHA compared to placebo. Although there was no statistically significant impact of EPA + DHA on individual inflammatory responses (tumor necrosis factor- (TNF-), IL-6, monocyte chemotactic protein (MCP-1), IL-1 receptor agonist (IL-1RA), IL-10, C-reactive protein (CRP), serum amyloid A (SAA)), there was a pattern of lower responses across all biomarkers with high-dose (nine of nine observed), but not low-dose EPA + DHA. ConclusionEPA + DHA at 3600 mg/day, but not 900 mg/day, reduced fever and had a pattern of attenuated LPS induction of plasma inflammatory markers during endotoxemia. Clinically and nutritionally relevant long-chain n-3 PUFA regimens may have specific, dose-dependent, anti-inflammatory actions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据