期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 57, 期 8, 页码 1378-1389出版社
WILEY
DOI: 10.1002/mnfr.201200827
关键词
Asthma; Eicosanoid; Lipidomics; Omega-3; Oxylipin
资金
- Center for Allergy Research
- Ake Wibergs Stiftelse, Jeanssons Stiftelse, Fredrik and Ingrid Thurings Stiftelse
- Swedish Medical Research Council [10350]
- CIDaT Vinnova
- Torsten & Ragnar Soderberg Foundation
- NIEHS SBRP [p42 ES004699]
- American Asthma Association [09-0269]
- Bernard Osher Initiative for Research on Severe Asthma
- Asthma Foundation of New South Wales
- Canada Research Chair in Airway Inflammometry
ScopeIn contrast to well-characterized PUFA levels in serum, little is known regarding their downstream metabolic products. However, many of these compounds are lipid mediators with prominent roles during pro- and antiinflammatory processes. Methods and resultsIn this double blind crossover study on asthmatics, shifts in serum levels of -3 and -6 PUFA-derived oxidized fatty acids (e.g. eicosanoids, oxylipins) were quantified following dietary fish oil supplementation. Serum was obtained from subjects following fasting at three occasions; (i) prior to supplementation, (ii) following a 3-week supplement intake of either placebo or fish oil, and (iii) following a 3-week washout period with a subsequent 3-week period of either fish oil or placebo supplement. A total of 87 oxylipins representing cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) metabolic pathways were screened via LC-MS/MS. CYP- and 15-LOX-derived EPA- and CYP-derived DHA oxylipins. Conclusion PUFAs affects not only PUFA levels, but importantly also the downstream metabolic profile.
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