期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 56, 期 6, 页码 854-865出版社
WILEY
DOI: 10.1002/mnfr.201200096
关键词
Metabolic syndrome; Inflammation; NF-kB; Postprandial state; Monounsaturated fatty acids
资金
- European community (LIPGENE European Integrated Proyect) [505944]
- Consejeria de Salud [07/43, PI-0193/2009]
- Consejeria de Innovacion
- Proyecto de investigacion de excelencia
- Junta de Andalucia [P06-CTS-01425]
- Spanish Ministry of Education and Science [AGL2006-01979/ALI, AGL2009-12270]
- Spanish Ministry of Health [CB06/03/0047]
Scope: Our aim was to investigate whether the inflammatory state associated to metabolic syndrome (MetS) patients is affected by diets with different fat quality and quantity. Methods and results: Seventy-five subjects from LIPGENE cohort were included in this feeding trial and randomly assigned to one of four diets: high saturated fatty acids (HSFA); high monounsaturated fatty acids (HMUFA) and two low-fat, high complex carbohydrate (LFHCC) diets, supplemented with long-chain n-3 polyunsaturated fatty acids (LFHCC n-3) or placebo (LFHCC), for 12 weeks each. A postprandial fat challenge, reflecting the intervention dietary fat composition, was conducted post-intervention. The HMUFA diet significantly reduced postprandial nuclear transcription factor-kappaB (NF-kB) activity and the nuclear p65 protein levels relative to fasting values (p < 0.05). Furthermore, we observed a postprandial decrease in this protein with the HMUFA diet compared with the HSFA and LFHCC diets (p < 0.05). The postprandial response of inhibitory molecule from NF-kB mRNA levels increased with the HMUFA diet compared with the HSFA and LFHCC n-3 diets (p < 0.05). Postprandial tumor necrosis factor-alpha and Metalloproteinase 9 mRNA levels were also reduced after the HMUFA diet compared with the HSFA diet (p < 0.05). Conclusion: Our results indicate that the long-term consumption of a healthy diet model with HMUFA attenuates the postprandial inflammatory state associated with MetS.
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