期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 56, 期 1, 页码 116-125出版社
WILEY
DOI: 10.1002/mnfr.201100524
关键词
DNA methylation; Hepatocarcinogenesis; Histone methylation; Methyl-deficient diet; MicroRNA
A chronic deficiency of major dietary methyl group donors methionine, choline, folic acid, and vitamin B12 can induce the development of liver cancer in rodents. Feeding methyl-deficient diets causes several molecular alterations, including altered lipid metabolism, oxidative stress, deregulated one-carbon metabolism, and a number of epigenetic abnormalities that result in progressive liver injury culminating in the development of primary liver tumors. Importantly, this methyl-deficient model of endogenous hepatocarcinogenesis is one of the most relevant models of human liver carcinogenesis that allows studying liver cancer pathogenesis by substantially complementing many shortcomings of humans-only studies. In this review, we describe molecular changes and their role in pathogenesis of liver carcinogenesis induced by methyl deficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据