期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 55, 期 7, 页码 1036-1043出版社
WILEY
DOI: 10.1002/mnfr.201000654
关键词
Curcumin; Pulmonary cancer; Transgenic mice; Turmeric; VEGF
资金
- National Science Council [NSC-98-2313-B-005-012]
- Council of Agriculture [COA-97-6.2.1-U1(9)]
- Ministry of Education, Taiwan, Republic of China
Scope: We investigated the inhibition of pulmonary tumor formation through treatment with curcumin in transgenic mice. Methods and results: In this study, a strain of transgenic mice carrying human vascular endothelial growth factor A(165) (hVEGF-A(165)) gene to induce pulmonary tumor was used as an in vivo cancer therapy model. We found that curcumin significantly reduced hVEGF-A(165) overexpression to normal, specifically in Clara cells of the lungs of transgenic mice, and suppressed the formation of tumors. In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels. We also noticed a reduction of Cyclin A and Cyclin B after curcumin treatment that had an effect on the cell cycle. Curcumin-induced inhibition of Cyclin A and Cyclin B likely results in decreased progression through S and G2/M phases. These results demonstrated that the expression of proteins involved in the S to M phase transition in transgenic mice is suppressed by curcumin. Conclusion: A Data suggest that a blockade of the cell cycle may be a critical mechanism for the observed effects on vasculogenesis and angiogenesis following treatment with curcumin.
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