期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 54, 期 5, 页码 631-640出版社
WILEY
DOI: 10.1002/mnfr.200900445
关键词
alpha-Tocopherol; Antioxidant; Cell death; Lipid raft; Signal transduction
资金
- Universite de Bourgogne
- Centre Hospitalier Universitaire de Dijon
- Conseil Regional de Bourgogne
- INSERM (Institut National de la Sante Et de la Recherche Medicale)
- ANR (Agence Nationale de la Recherche-Atherolip Project)
- Fondation de France
Vitamin E is composed of closely related compounds, including tocopherols and tocotrienols. Studies of the last decade provide strong support for a specific role of alpha-tocopherol in cell signalling and the regulation of gene expression. It produces significant effects on inflammation, cell proliferation and apoptosis that are not shared by other vitamin E isomers with similar antioxidant properties. The different behaviours of vitamin E isomers might relate, at least in part, to the specific effects they exert at the plasma membrane. alpha-Tocopherol is not randomly distributed throughout the phospholipicl bilayer of biological membranes, and as compared with other isomers, it shows a propensity to associate with lipid rafts. Distinct aspects of vitamin E transport and metabolism is discussed with emphasis on the interaction between alpha-tocopherol and lipid rafts and the consequences of these interactions on cell metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据