期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 53, 期 -, 页码 S36-S43出版社
WILEY
DOI: 10.1002/mnfr.200800214
关键词
Benzene-1,2,4-triol; Elimination; 2-Methoxybenzene-1,4-diol; Sesamol; Sesamol glucuronide
资金
- National Science Council, Taiwan, Republic of China [NSC 93-2313-B-002-049, NSC 94-2313-B-002-016]
Sesamol, generally regarded as a main antioxidative component in sesame oil, is generated from sesamolin upon roasting of sesame seed or during bleaching process of sesame oil. This investigation studied the bioavailability and excretion of sesamol in Sprague-Dawley rats. After oral administration of sesamol (p.o. 100 mg/kg) to SD rats, the changes in concentration of sesamol were determined in various excreta within 24 h period. Our results showed that sesamol conjugated metabolites were rapidly eliminated from urine and feces in 0-4 h. The majority of intact sesamol glucuronide was excreted in the urine. It is suggested that sesamol conjugated metabolites are primarily eliminated from the plasma via the kidney by active tubular secretion. LC-MS/MS analyses of rat excreta showed that sesamol can be converted to 2-methoxybenzene-1,4-diol and benzene-1,2,4-triol in vivo by rat.
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