期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 53, 期 9, 页码 1104-1111出版社
WILEY
DOI: 10.1002/mnfr.200800569
关键词
Absorption; Aspalathin; C-glycoside; Flavonoid; Methylation
Human bioavailability of the flavonoid dihydrochalcones is little understood, and no evidence exists for C-glycosyl flavonoid absorption in humans. The present study uses catechol-O-methyltransferase to generate methylated metabolites of aspalathin (a C-glycosyl dihydrochalcone from rooibos tea). One of the methylated forms, both with and without glucuronidation, was detected using LC-MS/MS in the urine of human subjects (n = 6), demonstrating that deglycosylation is not a prerequisite for C-glycosyl flavonoid absorption. Methylation is catalysed by both intestine and liver cytosolic extracts. The results show that flavonoid C-glycosides are methylated and glucuronidated in vivo in an intact form in humans.
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