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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Lovastatin enhances Aβ production and senile plaque deposition in female Tg2576 mice
IH Park et al.
NEUROBIOLOGY OF AGING (2003)
Statins promote potent systemic antioxidant effects through specific inflammatory pathways
MH Shishehbor et al.
CIRCULATION (2003)
Expression of liver X receptor target genes decreases cellular amyloid β peptide secretion
Y Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
MA Pappolla et al.
NEUROLOGY (2003)
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
EG Lund et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cholesterol homeostasis and function in neurons of the central nervous system
FW Pfrieger
CELLULAR AND MOLECULAR LIFE SCIENCES (2003)
ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
MA Wollmer et al.
NEUROBIOLOGY OF AGING (2003)
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed et al.
SCIENCE (2003)
Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease
GL Vega et al.
ARCHIVES OF NEUROLOGY (2003)
Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease
J Poirier
TRENDS IN MOLECULAR MEDICINE (2003)
The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted
B Grziwa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
R Ehehalt et al.
JOURNAL OF CELL BIOLOGY (2003)
Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains
MD Ledesma et al.
EMBO REPORTS (2003)
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
A Papassotiropoulos et al.
ARCHIVES OF NEUROLOGY (2003)
Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
L Li et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
S Youssef et al.
NATURE (2002)
Intraneuronal Alzheimer Aβ42 accumulates in multivesicular bodies and is associated with synaptic pathology
RH Takahashi et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AβP (1-40) and (1-42) peptides
N Arispe et al.
FASEB JOURNAL (2002)
Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
KN Dahlgren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Statin therapy for Alzheimer's disease - Will it work?
SS Petanceska et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
aph-1 and pen-2 are required for notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation
R Francis et al.
DEVELOPMENTAL CELL (2002)
Interactions of amyloid β-protein with various gangliosides in raft-like membranes:: Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid
A Kakio et al.
BIOCHEMISTRY (2002)
Cerebrospinal fluid Aβ40 and Aβ42:: Natural course and clinical usefulness
M Shoji
FRONTIERS IN BIOSCIENCE-LANDMARK (2002)
Statins inhibit Aβ-neuro toxicity in vitro and Aβ-induced vasoconstriction and inflammation in rat aortae
D Paris et al.
ATHEROSCLEROSIS (2002)
Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice
H Hayashi et al.
NEUROREPORT (2002)
Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice
FS Shie et al.
NEUROREPORT (2002)
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
S Wahrle et al.
NEUROBIOLOGY OF DISEASE (2002)
Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
K Rockwood et al.
ARCHIVES OF NEUROLOGY (2002)
Genotype and phenotype in Alzheimer's disease
C Holmes
BRITISH JOURNAL OF PSYCHIATRY (2002)
Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
H Kolsch et al.
MOLECULAR PSYCHIATRY (2002)
Serum lipoprotein levels, statin use, and cognitive function in older women
K Yaffe et al.
ARCHIVES OF NEUROLOGY (2002)
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease
S Iivonen et al.
NEUROSCIENCE (2002)
On the turnover of brain cholesterol in patients with Alzheimer's disease.: Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
N Bogdanovica et al.
NEUROSCIENCE LETTERS (2001)
Reduction in cholesterol and sialic acid content protects cells from the toxic effects of β-amyloid peptides
SSS Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
PS1N-and C-terminal fragments form a complex that functions in APP processing and Notch signaling
D Levitan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Human apolipoprotein E4 accelerates β-amyloid deposition in APPsw transgenic mouse brain
DB Carter et al.
ANNALS OF NEUROLOGY (2001)
A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease
LM Refolo et al.
NEUROBIOLOGY OF DISEASE (2001)
Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L Puglielli et al.
NATURE CELL BIOLOGY (2001)
Cholesterol, a modulator of membrane-associated Aβ-fibrillogenesis and neurotoxicity
CM Yip et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Probing the origins of increased activity of the E22Q Dutch mutant Alzheimer's β-amyloid peptide
F Massi et al.
BIOPHYSICAL JOURNAL (2001)
ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein
N Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
K Fassbender et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
E Kojro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
T Wyss-Coray et al.
NATURE MEDICINE (2001)
Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice
GP Eckert et al.
NEUROREPORT (2001)
Acyl coenzyme A:cholesterol acyltransferase types 1 and 2:: structure and function in atherosclerosis
LL Rudel et al.
CURRENT OPINION IN LIPIDOLOGY (2001)
Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-Pick type C cells
T Yamazaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Lysosomal membrane damage in soluble Aβ-mediated cell death in Alzheimer's disease
K Ditaranto et al.
NEUROBIOLOGY OF DISEASE (2001)
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
MR D'Andrea et al.
HISTOPATHOLOGY (2001)
Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APPV717F transgenic mice
MC Irizarry et al.
ACTA NEUROPATHOLOGICA (2000)
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
B Wolozin et al.
ARCHIVES OF NEUROLOGY (2000)
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
G Yu et al.
NATURE (2000)
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo et al.
NEUROBIOLOGY OF DISEASE (2000)
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
J Näslund et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
DM Holtzman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Cholesterol depletion of enterocytes - Effect on the Golgi complex and apical membrane trafficking
GH Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Current perspectives on statins
DJ Maron et al.
CIRCULATION (2000)
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