期刊
MOLECULAR NEUROBIOLOGY
卷 44, 期 3, 页码 313-320出版社
SPRINGER
DOI: 10.1007/s12035-011-8201-5
关键词
Flamingo; Celsr; Cadherins; GPCR-adhesion molecules; Dendrite formation; Axon guidance; Planar cell polarity; Golden goal
The Flamingo/Celsr seven-transmembrane cadherins represent a conserved subgroup of the cadherin superfamily involved in multiple aspects of development. In the developing nervous system, Fmi/Celsr control axonal blueprint and dendritic morphogenesis from invertebrates to mammals. As expected from their molecular structure, seven-transmembrane cadherins can induce cell-cell homophilic interactions but also intracellular signaling. Fmi/Celsr is known to regulate planar cell polarity (PCP) through interactions with PCP proteins. In the nervous system, Fmi/Celsr can function in collaboration with or independently of other PCP genes. Here, we focus on recent studies which show that seven-transmembrane cadherins use distinct molecular mechanisms to achieve diverse functions in the development of the nervous system.
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