期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 7, 期 285, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aaa5680
关键词
-
资金
- U.S. National Heart, Lung, and Blood Institute [R01-HL50490, R01-HL84228]
- Ministry of Education, Science, Sports, and Culture [0903570031]
- Medical Research Council-Public Health England (MRC-PHE) Centre for Environment and Health, National Institute for Health Research (NIHR) Biomedical Research Centre at Imperial College Healthcare National Health Service Trust
- Imperial College London
- NIHR Health Protection Research Unit on Health Impact of Environmental Hazards
- MRC-PHE Centre for Environment and Health
- National Institutes of Health Research (NIHR) [PDF-2012-05-456] Funding Source: National Institutes of Health Research (NIHR)
- Medical Research Council [MR/L01341X/1, MC_PC_12025] Funding Source: researchfish
- National Institute for Health Research [PDF-2012-05-456, NF-SI-0611-10136] Funding Source: researchfish
- MRC [MC_PC_12025, MR/L01341X/1] Funding Source: UKRI
Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton (H-1) nuclear magnetic resonance (NMR) spectroscopy and ion exchange chromatography to characterize the metabolic signatures of adiposity in the U.S. (n = 1880) and UK (n = 444) cohorts of the INTERMAP (International Study of Macro-and Micronutrients and Blood Pressure) epidemiologic study. Metabolic profiling of urine samples collected over two 24-hour time periods 3 weeks apart showed reproducible patterns of metabolite excretion associated with adiposity. Exploratory analysis of the urinary metabolome using H-1 NMR spectroscopy of the U.S. samples identified 29 molecular species, clustered in interconnecting metabolic pathways, that were significantly associated (P = 1.5 x 10(-5) to 2.0 x 10(-36)) with body mass index (BMI); 25 of these species were also found in the UK validation cohort. We found multiple associations between urinary metabolites and BMI including urinary glycoproteins and N-acetyl neuraminate (related to renal function), trimethylamine, dimethylamine, 4-cresyl sulfate, phenylacetylglutamine and 2-hydroxyisobutyrate (gut microbial co-metabolites), succinate and citrate (tricarboxylic acid cycle intermediates), ketoleucine and the ketoleucine/leucine ratio (linked to skeletal muscle mitochondria and branched-chain amino acid metabolism), ethanolamine (skeletal muscle turnover), and 3-methylhistidine (skeletal muscle turnover and meat intake). We mapped the multiple BMI-metabolite relationships as part of an integrated systems network that describes the connectivities between the complex pathway and compartmental signatures of human adiposity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据