期刊
MOLECULAR MICROBIOLOGY
卷 93, 期 4, 页码 599-608出版社
WILEY
DOI: 10.1111/mmi.12708
关键词
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资金
- Massachussets Life Sciences Center
- NSF GRFP [DGE-1144152]
- Molecules Cells an Organisms Training Grant [GM-07598]
Over a decade of studies have tackled the question of how FtsK/SpoIIIE translocases establish and maintain directional DNA translocation during chromosome segregation in bacteria. FtsK/SpoIIIE translocases move DNA in a highly processive, directional manner, where directionality is facilitated by sequences on the substrate DNA molecules that are being transported. In recent years, structural, biochemical, single-molecule and high-resolution microscopic studies have provided new insight into the mechanistic details of directional DNA segregation. Out of this body of work, a series of models have emerged and, ultimately, yielded two seemingly opposing models: the loading model and the target search model. We review these recent mechanistic insights into directional DNA movement and discuss the data that may serve to unite these suggested models, as well as propose future directions that may ultimately solve the debate.
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