期刊
MOLECULAR MICROBIOLOGY
卷 89, 期 4, 页码 583-595出版社
WILEY-BLACKWELL
DOI: 10.1111/mmi.12307
关键词
-
资金
- NIH [4R00GM090732]
- NSF [MCB-1149925]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1149925] Funding Source: National Science Foundation
Natural transformation is a major mechanism of horizontal gene transfer in bacteria. By incorporating exogenous DNA elements into chromosomes, bacteria are able to acquire new traits that can enhance their fitness in different environments. Within the past decade, numerous studies have revealed that natural transformation is prevalent among members of the Vibrionaceae, including the pathogen Vibrio cholerae. Four environmental factors: (i) nutrient limitation, (ii) availability of extracellular nucleosides, (iii) high cell density and (iv) the presence of chitin, promote genetic competence and natural transformation in Vibrio cholerae by co-ordinating expression of the regulators CRP, CytR, HapR and TfoX respectively. Studies of other Vibrionaceae members highlight the general importance of natural transformation within this bacterial family.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据