期刊
MOLECULAR MICROBIOLOGY
卷 76, 期 1, 页码 1-11出版社
WILEY
DOI: 10.1111/j.1365-2958.2010.07086.x
关键词
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资金
- Swiss National Science Foundation [31003A_125369]
- University of Zurich
- Institut Pasteur, the Centre National de la Recherche (CNRS)
- NIH [2 R01 AI44212]
- Network of Excellence 'Europathogenomics' [LSHB-CT-2005-512061]
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- University of Lyon
- Australian National Health and Medical Research Council (NHMRC)
- Australian Research Council (ARC)
- Swiss National Science Foundation (SNF) [31003A_125369] Funding Source: Swiss National Science Foundation (SNF)
P>Legionellosis or Legionnaires' disease is an emerging and often-fatal form of pneumonia that is most severe in elderly and immunocompromised people, an ever-increasing risk group for infection. In recent years, the genomics of Legionella spp. has significantly increased our knowledge of the pathogenesis of this disease by providing new insights into the evolution and genetic and physiological basis of Legionella-host interactions. The seventh international conference on Legionella, Legionella 2009, illustrated many recent conceptual advances in epidemiology, pathogenesis and ecology. Experts in different fields presented new findings on basic mechanisms of pathogen-host interactions and bacterial evolution, as well as the clinical management and environmental prevalence and persistence of Legionella. The presentations revealed remarkable facts about the genetic and metabolic basis of the intracellular lifestyle of Legionella and reported on its striking ability to manipulate host cell processes by molecular mimicry. Together, these investigations will lead to new approaches for the treatment and prevention of Legionnaires' disease.
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