期刊
MOLECULAR MEMBRANE BIOLOGY
卷 27, 期 7, 页码 232-246出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09687688.2010.516276
关键词
Phospholipid micelles; cancer targeting; stimuli-sensitive nanocarriers
Phospholipid micelles have proven to be the versatile pharmaceutical nanocarrier of choice for the delivery of poorly soluble chemotherapeutics for cancer therapy using various treatment modalities. Phospholipid micelles are typically expected to increase the accumulation of the loaded drugs in tumour tissues by taking advantage of the enhanced permeability and retention effect and by ligand-mediated active targeting. Furthermore, by tailoring the composition of the micelles, it is possible to enhance the intracellular delivery of the cargo. This review highlights the important advancements in our laboratory with polyethyleneglycol phosphatidylethanolamine (PEG-PE)-based micellar drug delivery systems for improvement of the therapeutic efficacy of poorly soluble anticancer drugs.
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