期刊
MOLECULAR MEMBRANE BIOLOGY
卷 26, 期 1-2, 页码 80-92出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09687680802649582
关键词
Palmitoylation; GTPase; isoforms; plasma membrane; nanoclusters
资金
- NIH [GM066717]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM066717] Funding Source: NIH RePORTER
Ras proteins have become paradigms for isoform- and compartment-specific signaling. Recent work has shown that Ras isoforms are differentially distributed within cell surface signaling nanoclusters and on endomembranous compartments. The critical feature regulating Ras protein localization and isoform-specific functions is the C-terminal hypervariable region (HVR). In this review we discuss the differential post-translational modifications and reversible targeting functions of Ras isoform HVR motifs. We describe how compartmentalized Ras signaling has specific functional consequences and how cell surface signaling nanoclusters generate precise signaling outputs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据