期刊
MOLECULAR MEMBRANE BIOLOGY
卷 26, 期 5-7, 页码 309-U48出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09687680903164101
关键词
2B; polio virus; coxsackie virus; membrane proteins; assembly; channels
资金
- IRC [GR/R45650/01]
- MRC [G000852]
2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations a putative tetrameric bundle model of 2B is generated. The bundles show a pore lining motif of three lysines followed by a serine. The bundle is discussed in terms of different possible orientations of the helices in the membrane and the consequences this has on the in vivo activity of 2B.
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