期刊
MOLECULAR MEDICINE REPORTS
卷 9, 期 5, 页码 1982-1988出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2014.2012
关键词
ovarian cancer; cancer stem cells; self-renewal; 7-difluoromethoxyl-5,4 '-di-n-octyl genistein; FOXO3a
资金
- National Natural Science Foundation of China [81301894]
- Guangdong Province Science and Technique Department Item of China [2012B031800271]
- Guangzhou Science and Information Bureau Item of China [20130000015]
Carcinogenesis is predominantly dependent on the cancer stem cells (CSCs) residing or populating within the cancer. We previously demonstrated that the novel synthetic genistein analogue, 7-difluoromethoxy1-5,4'-di-n-octylgenistein (DFOG), induced apoptotic cell death of ovarian and gastric cancer cells. The present study demonstrated that sphere-forming cells (SFCs) derived from the ovarian cancer cell-line SKOV3 possessed ovarian cancer stem-like cell (OCSLC) properties, including self-renewal and high tumorigenicity. DFOG may be effective in inhibiting the self-renewal capacity of SFCs derived from the SKOV3 cell line. DFOG decreased the level of phosphorylated FOXO3a protein in SKOV3 cell-derived SFCs. The inhibition of FOXO3a expression by siRNA significantly attenuated the ability of DFOG to inhibit the self-renewal capacity of SKOV3-derived SFCs. Our results suggested that DFOG has been demonstrated to significantly inhibit the self-renewal capacity of ovarian cancer stem cells (OCSCs) through a mechanism partly dependent on the activation of FOXO3a.
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