期刊
MOLECULAR MEDICINE REPORTS
卷 9, 期 5, 页码 1806-1812出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2014.2031
关键词
claudin; mice
资金
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2013R1A2A2A05004582]
- National Research Foundation of Korea [2013R1A2A2A05004582] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Claudins (CLDNs) are tetraspan transmembrane proteins, which are components of tight junctions. The CLDN family is composed of 27 members that are responsible for paracellular transport and certain CLDNs form charge-selective ion channels. CLDNs have two extracellular loops, and the charge of the first extracellular loop determines the ion selectivity of each CLDN. Although the expression and function of each CLDN have been previously investigated, the distribution of CLDNs in various target organs remains to be determined. In the present study, the tissue-specific mRNA distribution of CLDNs (1-5, 7-8, 10a and b, 11-12, 14-17 and 19) in the duodenum, ileum, colon, kidney, liver and lung were defined. Among the tested CLDNs, CLDN1, 2, 12 and 16 were selected for further investiagtion. It was observed that CLDN1, CLDN2 and CLDN12 transcripts and proteins were particularly abundant in the investigated organs. Notably, immune-reactive CLDN16 was detected in a tissue-specific manner and shown in the renal tubules and portal vein. The tested CLDNs were localized to intercellular apical junctions in the epithelium of the intestine, renal tubule and bronchus. Based on this novel information, the presence of several types of CLDNs is of interest as CLDNs may promote or dampen the paracellular diffusion of specific ions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据