期刊
MOLECULAR MEDICINE REPORTS
卷 8, 期 3, 页码 737-740出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2013.1601
关键词
caffeine; memory; brain neurotrophic derived factor; TrkB; Alzheimer's disease
资金
- Principal Fund for Clinical Medicine
- Science and Technology Initializing Fund from the First Affiliated Hospital of Liaoning Medical College [FYK201205]
- Youth Science and Technology Initializing Fund from the First Affiliated Hospital of Liaoning Medical College [FY2012-01]
- Youth Science and Technology Initializing Fund from Liaoning Medical College [Y2012Z001]
The objective of this study was to investigate the effects of varying doses of caffeine on memory impairment and the expression of brain neurotrophic derived factor (BNDF) and TrkB in PS1/APP double transgenic mouse models. PS1/APP double transgenic mice were administered 0.3 ml/day of saline, 1.5 mg/day of caffeine or 0.75 mg/day of caffeine for eight weeks. A water maze test and western blotting were used to determine the memory capability and expression of hippocampal BNDF and TrkB of the mice. The results demonstrated that 0.75 mg/day and 1.5 mg/day doses of caffeine significantly increased memory capability and the expression of hippocampal BDNF and TrkB in PS1/APP mice with a dose-response effect. The results suggested that chronic caffeine treatment may reverse memory impairment in PS1/APP transgenic mice, and BDNF and its receptor TrkB, may be involved in this process.
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