期刊
MOLECULAR MEDICINE REPORTS
卷 7, 期 3, 页码 761-766出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2012.1254
关键词
oral squamous cell carcinoma; long non-coding RNAs; salivary
资金
- Research Grants of Shenzhen Science and Technology Project [ZYA201106080030A]
- Fundamental Research Funds for the Central Universities of China [21610404]
- Scientific Research Foundation of Jinan University [50624023]
- Medical Science and Technology Foundation of Guangdong
- National Natural Science Foundation of China [81102510]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
Oral squamous cell carcinoma (OSCC) is a common and lethal malignancy. Thus, improvement in current knowledge of molecular changes associated with OSCC is urgently needed to explore novel avenues of diagnostics and treatment of this disease. While aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with certain types of cancer, including lung, breast and prostate carcinomas, their expression pattern and biological relevance in OSCC is currently unknown. In the present study, the relative abundance of a collection of lncRNAs in tissue or saliva samples from OSCC patients was investigated. It was shown that subsets of lncRNAs are expressed across non-tumor, tumor and metastatic tissue samples. Some detected lncRNAs were shown to be aberrantly expressed in cases of oral cancer and metastasis. Moreover, whole saliva contained a detectable amount of some lncRNAs, which appeared to be potential markers for OSCC. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据