期刊
MOLECULAR MEDICINE REPORTS
卷 6, 期 5, 页码 955-960出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2012.1019
关键词
mesenchymal stem cells; prostate cancer cell; interleukin-1 alpha; transforming-growth factor-beta
资金
- Science Foundation for Young Scientists of Guangxi [0991075]
- Key Research Project of Guangxi Health Department [2011080]
- National Natural Science Foundation [2011080, 30860329]
- Guangxi Natural Science Foundation [2010gxnsfa013240]
Mesenchymal stem cells (MSCs) are generally used in tissue engineering, regenerative medicine and therapy for immune disorder disease. MSCs are also employed as drug carriers for tumor therapy due to their ability to migrate to tumor tissue. However, due to the immunosuppressive function of MSCs, the application of MSCs in prostate cancer therapy remains limited. In this study, we investigated the underlying mechanism by which MSCs enable prostate cancer cells to escape from immune surveillance in the inflammatory microenvironment. Firstly, we demonstrated that compared with the control groups, MSCs pretreated with IL-1 alpha effectively promoted the growth of the mouse prostate cancer cell line RM-I in vivo. Furthermore, when RM-I prostate cancer cells were co-injected with MSCs pretreated with IL-1 alpha, tumor incidence significantly increased in allogeneic recipients. In addition, we investigated the mechanism through which MSCs promote the ability of RM-I cells to escape from immune injury. The results revealed that IL-1 alpha led to the upregulation of TGF-beta in MSCs. The inflammatory cytokine-induced promotive effect of MSCs on RM-I cells in vivo was inhibited by TGF-beta siRNA. The results of our study suggest that inflammatory cytokines induce the immunosuppressive function of MSCs which enables prostate cancer cells to escape from immune injury.
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