4.4 Article Proceedings Paper

Ligand Efficiency Indices (LEIs): More than a Simple Efficiency Yardstick

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

Emanuele Perola

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Review Pharmacology & Pharmacy

Conciliating binding efficiency and polypharmacology

Jordi Mestres et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Article Biochemistry & Molecular Biology

Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin

Ole A. Andersen et al.

CHEMISTRY & BIOLOGY (2008)

Review Chemistry, Medicinal

Recent developments in fragment-based drug discovery

Miles Congreve et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities

Tiqing Liu et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Biochemistry & Molecular Biology

Lead-like, drug-like or pub-like: how different are they?

Tudor I. Oprea et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)

Review Pharmacology & Pharmacy

Ligand efficiency indices for effective drug discovery

Cele Abad-Zapatero

EXPERT OPINION ON DRUG DISCOVERY (2007)

Review Biotechnology & Applied Microbiology

A decade of fragment-based drug design: strategic advances and lessons learned

Philip J. Hajduk et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Biotechnology & Applied Microbiology

Opinion - How many drug targets are there?

John P. Overington et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Chemistry, Medicinal

Fragment-based drug design: How big is too big?

Philip J. Hajduk

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Chemistry, Medicinal

The PDBbind database: Methodologies and updates

RX Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Navigating chemical space for biology and medicine

C Lipinski et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

An automated PLS search for biologically relevant QSAR descriptors

M Olah et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2004)

Review Biochemistry & Molecular Biology

Chemical space navigation in lead discovery

TI Oprea

CURRENT OPINION IN CHEMICAL BIOLOGY (2002)

Article Chemistry, Applied

Chemography: The art of navigating in chemical space

TI Oprea et al.

JOURNAL OF COMBINATORIAL CHEMISTRY (2001)

Article Pharmacology & Pharmacy

Drug-like properties and the causes of poor solubility and poor permeability

CA Lipinski

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)