期刊
MOLECULAR IMMUNOLOGY
卷 62, 期 2, 页码 289-295出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2014.02.008
关键词
Antibody; Atg5; Autophagy; B cell; Blimp-1; Endoplasmic reticulum; ER-phagy; Immunological memory; Multiple myeloma; Plasma cell; Proteostasis; Reticulophagy; Ubiquitin; Unfolded protein response; XBP-1
资金
- Multiple Myeloma Research Foundation
- Italian Ministry of Health [1143560]
- Italian Association for Cancer Research (AIRC) [14691, 9965]
Plasma cells, the terminal effectors of the B lymphoid lineage, are responsible for the humoral arm of adaptive immunity. Their differentiation from B cells entails a profound cellular reshaping inherently associated with stress. Autophagy is a conserved adaptive cellular strategy recently implicated in differentiation and immunity. We identified a novel autophagic function in plasma cells. Autophagy restricts the expression of the transcriptional repressor Blimp-1 and immunoglobulins through a selective negative control on the endoplasmic reticulum and its stress signaling response, thereby optimizing energy and viability. As a result, autophagy in vivo sustains antibody responses, and is an essential intrinsic determinant of the bone marrow long-lived plasma cell niche. Here, I discuss several immune and biomedical implications, and experimental issues to be addressed in the near future. (C) 2014 Published by Elsevier Ltd.
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