期刊
MOLECULAR IMMUNOLOGY
卷 48, 期 5, 页码 769-775出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2010.12.002
关键词
Innate immunity; MHC class I related; Klebsiella pneumoniae
资金
- Ligue regionale contre le Cancer
- Association pour la Recherche contre le Cancer (ARC)
- Fondation pour la Recherche Medicale (FRM)
- Agence Nationale pour la Recherche (ANR)
As opposed to the well established role of MHC-linked, polymorphic, class I (MHC-I) genes in adaptive immunity, a universal role for non-conventional MHC-I is unknown, thus requiring a case-by-case study. The MHC unlinked, monomorphic, but beta(2)microglobulin (beta(2)m)-associated MHC class I related MR1 molecule interacts with a semi-invariant TCR. The pathophysiology of this interaction or more importantly of this peculiar MHC-I remains mostly unknown. Recently it was shown that beta(2)m deficient mice were more susceptible to infection by Klebsiella pneumoniae, a widely spread Gram-negative bacteria that causes diverse and often severe ailments in man. Here we demonstrate, using both an in vivo imaging system and survival tests, the increased susceptibility to K. pneumoniae (but not to several other Gram negative bacteria) of MR1 deficient mice. This is accompanied by a consequent change in body temperature and systemic cytokine profile. Hence MR1 controls K. pneumoniae infection in vivo. (C) 2010 Elsevier Ltd. All rights reserved.
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