期刊
MOLECULAR IMMUNOLOGY
卷 48, 期 9-10, 页码 1114-1120出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2011.02.004
关键词
Salmonella Choleraesuis; Toll-like receptor; Single nucleotide polymorphism; Molecular modeling; Pig
资金
- Ministry of Agriculture, Forestry, and Fisheries of Japan
- Japan Racing Association
Salmonella enterica serovar Choleraesuis (SC) is a highly invasive pathogen that causes enteric and septicemic diseases in pigs. Although there have been some reports on gene expression profiles in the course of infection with SC in pigs, little is known about the genes involved in the infection. By measuring activation, as represented by nuclear factor-kappa B activity, after stimulation by the pathogen, we showed the involvement of Toll-like receptor (TLR) 5 and the TLR2-TLR1 heterodimer in the recognition of SC. We previously found single nucleotide polymorphisms(SNPs) in the TLRs of various pig populations. Here we demonstrated that the polymorphisms resulting in amino acid changes TLR5(R148L), TLR5(P402L), and TLR2(V703M) attenuated the responses to SC by the cells transfected with the TLR genes. Each of these three SNPs was differently restricted in distribution among breeds. These results suggest that there are differences in resistance to salmonellosis among breeds; these differences may be of great importance for the pig industry in terms of breeding and vaccine development. (C) 2011 Elsevier Ltd. All rights reserved.
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