期刊
MOLECULAR IMMUNOLOGY
卷 47, 期 4, 页码 640-648出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2009.10.013
关键词
Calcium; Mast cell; Immune cell; Cell activation; Cell survival
资金
- MEXT
- Nihon University
Ca2+ is a highly versatile intracellular second messenger in many cell types, and regulates many complicated cellular processes, including cell activation, proliferation and apoptosis. Influx of Ca2+ from the extracellular fluid is required for sustained elevation of the cytosolic Ca2+ concentration and full activation of Ca2+-dependent processes. It is widely accepted that Ca2+ release-activated Call channels are the major routes of Ca2+ influx in electrically non-excitable cells, including hematopoietic cells, whereas voltage-gated Ca2+ channels such as L-type Ca2+ channels (LTCCs) serve as the principal routes of Ca2+ entry into electrically excitable cells such as neurons and myocytes. However, recent pharmacological and molecular genetic studies have revealed the existence of functional LTCCs and/or LTCC-like channels in a variety of immune cells including mast cells. In this article, we review recent advances in our understanding of Ca2+ signaling in immune cells with a special interest in mast cells. We highlight roles for LTCCs in antigen receptor-mediated mast cell activation and survival. (C) 2010 Elsevier Ltd. All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据