期刊
MOLECULAR IMMUNOLOGY
卷 46, 期 16, 页码 3207-3217出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2009.08.013
关键词
C3adesArg; G-protein coupled receptor; C5L2; gpr77; Adipocytes; Triglyceride synthesis
资金
- Canadian Institute of Health Research [MOP-64446]
- Obesity Training Program, CRIUCPQ
C5L2 is a recently identified receptor for C5a/C5adesArg, C3a and C3adesArg (ASP). C5a/C5adesArg bind with high affinity, with no identified activation. By contrast, some studies demonstrate C3a/ASP binding/activation to C5L2; others do not. Our aim is to critically evaluate ASP/C3adesArg-C5L2 binding and bioactivity. Cell-associated fluorescent-ASP (FI-ASP) binding to C5L2 increased from transiently transfected < stably transfected
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