期刊
MOLECULAR IMMUNOLOGY
卷 46, 期 5, 页码 761-772出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2008.09.026
关键词
Complement Receptor 1; Review; Therapeutic implications; Complement genetics; Disease associations
资金
- Indian Council of Medical Research
- Council of Scientific and Industrial Research, India
- Department of Science and Technology, India
Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This review brings forth a composite view of the current understanding on the structure, functions, genetics, disease associations and therapeutic implications of CR1. (C) 2008 Elsevier Ltd. All rights reserved.
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