期刊
MOLECULAR IMMUNOLOGY
卷 45, 期 5, 页码 1231-1240出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2007.09.014
关键词
peanut allergen; tree nut allergen; vicilin; IgE-binding epitope; epitope mapping; conformational analysis; IgE-binding cross-reactivity; Ana o 1; Ara h 1; Cor a 11; Jug r 2
Surface-exposed IgE-binding epitopes of close overall conformation were characterized on the molecular surface of three-dimensional models built for the vicilin allergens of peanut (Ara h 1), walnut (Jug r 2), hazelnut (Cor a 11) and cashew nut (Ana o 1). They correspond to linear stretches of conserved amino acid sequences mainly located along the C-terminus of the polypeptide chains. A glyco-epitope corresponding to an exposed N-glycosylation site could also interfere with the IgE-binding epitopes. All these epitopic regions should participate in the IgE-binding cross-reactivity commonly reported between tree nuts or between peanut and some tree nuts in sensitized individuals. Owing to this epitopic community which constitutes a risk of cross-sensitization, the avoidance or a restricted consumption of other tree nuts should be recommended to peanut-sensitized individuals. (c) 2007 Elsevier Ltd. All rights reserved.
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