期刊
MOLECULAR IMAGING AND BIOLOGY
卷 16, 期 6, 页码 838-845出版社
SPRINGER
DOI: 10.1007/s11307-014-0757-9
关键词
Dorsolateral prefrontal cortex; Medial prefrontal cortex; Deep brain stimulation; [F-18]FDG microPET; Addiction; Depression
资金
- Antwerp University, Belgium
- Antwerp University Hospital, Belgium
- IOF PoC grant of Antwerp University [45/FA020000/27/5823]
Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using mu PET. One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 Hz, 130 Hz or sham) in rats (n = 9) was followed by 2-deoxy-2-[(18) F] fluoro-d-glucose ([(18) F]FDG) mu PET. Sixty Hz DBS elicited significant hypermetabolism in the ipsilateral PL ([(18) F]FDG uptake +5.2 +/- 2.3 %, p < 0.05). At 130 Hz, hypometabolism was induced in the ipsilateral PL (-2.5 +/- 2.6 %, non-significant). Statistical parametric mapping revealed hypo and hypermetabolism clusters for both 60 and 130 Hz versus sham and show a certain state of alertness (increased activity in sensory and motor-related regions) mainly for 60 Hz. This study suggests the potential of 60 Hz PL mPFC DBS for the treatment of disorders associated with prefrontal hypofunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据