期刊
MOLECULAR IMAGING AND BIOLOGY
卷 15, 期 5, 页码 507-520出版社
SPRINGER
DOI: 10.1007/s11307-013-0648-5
关键词
Pharmacokinetics (PK); Molecular imaging; Nanoparticles; Carbon nanotube (CNT); Quantum dot (QD); Cancer; Angiogenesis; Positron emission tomography (PET); Fluorescence
资金
- University of Wisconsin Carbone Cancer Center
- National Institutes of Health [1R01CA169365-01A1]
- Department of Defense [W81XWH-11-1-0644]
- UW Graduate School
- UW Department of Radiology
With many desirable properties, nanoparticles hold tremendous potential for in vivo molecular imaging and improving the efficacy of small-molecule drugs. The pharmacokinetics (PK) and tissue distribution of nanoparticles largely define their in vivo performance and potential toxicity, which are fundamental issues that need to be elucidated. In this review article, we summarized how molecular imaging techniques (e.g., positron emission tomography, fluorescence imaging, etc.) can facilitate the investigation of PK profiles of nanoparticles using carbon nanotubes (CNTs) and quantum dots (QDs) as representative examples. Different imaging techniques can provide useful insights in monitoring the in vivo behavior and tissue distribution of these nanoparticles, and a number of strategies were utilized to optimize the PK profiles of CNTs and QDs. Based on the available literature reports, it can be concluded that chemical/physical properties of the nanoparticles (e.g., surface functionalization, hydrodynamic size, shape, surface charge, etc.), along with the administration routes/doses, can play critical roles in determining the PK and biodistribution pattern of nanoparticles. Robust chemistry for surface modification of nanoparticles is a prerequisite for successful future biomedical/clinical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据