期刊
MOLECULAR IMAGING AND BIOLOGY
卷 16, 期 1, 页码 95-101出版社
SPRINGER
DOI: 10.1007/s11307-013-0675-2
关键词
Head and neck cancer; Pulsed high-intensity focused ultrasound; Boron neutron capture therapy; F-18-FBPA-Fr; MicroPET
资金
- Taipei Veterans General Hospital, Taipei, Taiwan [V100A-045, VGHUST101-G1-2-3]
- National Research Program for Biopharmaceuticals (NRPB) at the National Science Council (NSC) of Taiwan
This study aims to demonstrate that pulsed high-intensity focused ultrasound (pulsed-HIFU) may enhance the fructose-conjugated 4-borono-L-phenylalanine (BPA-Fr) accumulation in tumor lesion using F-18-FBPA-Fr microPET scans. To the mice bearing orthotopic SASC03 human tongue squamous carcinoma xenograft, a 2-min pulsed-HIFU was applied to tumor. Immediately after pulsed-HIFU treatment, F-18-FBPA-Fr was intravenously injected, and biological characterizations including microPET imaging and biodistribution were conducted. Both biodistribution studies and microPET imaging performed after intravenous injection of F-18-FBPA-Fr revealed higher tumor uptake in HIFU-treated mice than that of the control. CD31 and Ki-67 histochemical staining of tumor sections and H&E staining of nearby normal tissues revealed no significant difference between the pulsed-HIFU-treated mice and the control. This study demonstrated that pulsed-HIFU was beneficial to the accumulation of boron drug in the head and neck tumor lesion and may enhance the therapeutic efficacy of clinical BNCT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据